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Updated: 24 min 4 sec ago

Encephalitis

Wed, 06/03/2026 - 10:10am

Article URL: https://burntsushi.net/encephalitis/

Comments URL: https://news.ycombinator.com/item?id=48384355

Points: 1

# Comments: 0

Categories: Hacker News

Kyxgo Technology

Wed, 06/03/2026 - 10:08am
Categories: Hacker News

Show HN: Genomi – make genome data manageable and queryable by AI agents

Wed, 06/03/2026 - 10:03am

Hey HN, I’m Matthew, one of the people building Genomi.

Many people have done a DNA test or sequencing in the past, but the results stay virtually dead on our computer, maybe we saw a report that came with it, but does anyone still remember what it said? I don't. What bothers me even more is that the world of DNA science actually evolves quite quickly, there are many new findings published every year and that may or may not be relevant to your DNA, but your old report, which I spent a fair amount on, will not have it! (though it has gotten much much cheaper lately)

I feel AI agent is the perfect tool to help me query and understand my own DNA, but I am immediately hesitant to feed my own file to an agent, not only the security risk of sending my own DNA file to them, but it simply doesn't work, the massive nature of the file will overflow the context window with excess data that gives me near to no value. So we built Genomi: an open-source local genomics harness for AI agents.

Genomi parses a VCF/gVCF or supported consumer DNA export, such as 23andMe or AncestryDNA, into a local SQLite index called the Active Genome Index (AGI, heh). The agent does not need the whole genome in context. Instead, it calls tools against the local index and public evidence sources as it sees fit. Today it exposes 80+ evidence-focused tools across genomics sources including variant lookup, gene/disease evidence, pharmacogenomics, GWAS/PRS context, population context, sequence/region utilities, etc.

The project is at an early stage and I welcome any feedback, please let me know what you guys think!

Comments URL: https://news.ycombinator.com/item?id=48384270

Points: 1

# Comments: 0

Categories: Hacker News

Show HN: Anywager – Inline prediction-market lookup for whatever you're reading

Wed, 06/03/2026 - 10:02am

I kept reading the news and social media thinking "there's probably a market on this," and never looking it up. So I built the lookup into the page.

Anywager scans the page you're on, highlights text that matches a live prediction market, and shows the question, odds, and a link to Kalshi on hover.

Right now, it only points you to Kalshi; it doesn't place bets yet. The direction I'm headed is collapsing that last step: see the claim, see the odds, and drop money on it --- frictionlessly --- all without leaving the site.

I'd like feedback on the matching especially, cause it tends to misfire sometimes. Ask me anything!

Comments URL: https://news.ycombinator.com/item?id=48384261

Points: 1

# Comments: 0

Categories: Hacker News

Shopify Is Down

Wed, 06/03/2026 - 10:00am

Article URL: https://www.shopifystatus.com

Comments URL: https://news.ycombinator.com/item?id=48384221

Points: 5

# Comments: 2

Categories: Hacker News

Show HN: Uno – Us vs. Them. Humans vs. AI version of the card game

Wed, 06/03/2026 - 9:58am

I love Uno, so for fun I made a web based multiplayer version of the game. Completely free, no ads, no accounts. Has some of my favorite custom “house” rules like stacking, shuffle hands, and numbers only!

Play friends or play AI. Chat with opponents. You can even bring your own AI

Comments URL: https://news.ycombinator.com/item?id=48384203

Points: 1

# Comments: 0

Categories: Hacker News

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