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GenBio AI just released an update to AIDO.ModelGenerator, a software package for adapting, benchmarking, and applying biological foundation models across multiple tasks and data types.

What it is

AIDO.ModelGenerator supports both GenBio AI models and popular open-source models like Enformer, ESM2, and scFoundation. It enables workflows for structure prediction, protein modeling, single-cell analysis, and spatial transcriptomics.

What’s new

New models:

• AIDO.StructurePrediction – biomolecular structure prediction across proteins, RNA, DNA, and ligands • AIDO.Protein-RAG – protein modeling with MSA and structure input • AIDO.Tissue – spatially aware cell modeling

New benchmark datasets:

• Cell age prediction • Cell-type classification • Cellular perturbation (Tahoe-100M)

Utilities for distributed training and hyperparameter tuning

Use cases Includes tutorials for:

• mRNA vaccine design • Predicting protein complexes • Simulated gene knockouts for target discovery

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Article URL: https://arxiv.org/abs/2504.11691

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Article URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC3191661/

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